Department of Chemistry and Biochemistry

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taro amagata

Taro Amagata

anderson Name: Amagata, Taro
Education: B.S. (1993) Osaka University of Pharmaceutical Sciences, Japan.
M.S. (1995) Osaka University of Pharmaceutical Sciences, Japan.
Ph.D. (1998) Osaka University of Pharmaceutical Sciences, Japan.
At SFSU since: 2008
Status: Assistant Professor
Office Location: TH641
Phone: (415) 338-7713
Email: anderson
Website:
Marine Natural Products Chemistry
Marine invertebrates such as sponges and tunicates have given continuous global attention as sources for pharmaceutical leads over the past three decades. Interestingly, recent studies have disclosed some of bioactive substances separated from marine invertebrates are produced by microorganisms. My research group focuses on exploring anti-cancer and anti-malaria potential leads from marine obligate microorganisms separated from marine sediments, algae and sponges. In my group, isolation of novel bioactive secondary metabolites is performed using concise and sophisticated methods employing a combination of a yeast halo assay and cutting edge dereplication techniques. My group also plans to perform medicinal chemistry and to identify gene clusters for promising bioactive compounds through collaborative research. 

Publications:

(22)    Kimberley N. White, Taro Amagata, Allen G. Oliver, Karen Tenney, Philip J. Wenzel and Phillip Crews. “Structure Revision and Density Functional Theory Study of Spiroleucettadine, a Sponge Alkaloid having a Bicyclic Core Meager in H-Atoms”. (J. Org. Chem. In press)

(21)      Taro Amagata, Tyler A. Johnson, Robert H. Cichewicz, Karen Tenney, Susan L. Mooberry, Joseph Media, Matthew Edelstein, Frederick A Valeriote and Phillip Crews. “Interrogating Bioactive Pharmacophore of the Latrunculin Chemotype by Investigating the Metabolites of Two Taxonomically Unrelated Sponges” (J. Med. Chem. In press)

(20)      Tyler A. Johnson, Taro Amagata, Allen G. Oliver, Karen Tenney, Frederick A. Valeriote, Phillip Crews. “The Unexpected Isolation of CTP-431, a Novel Thiopyrone from the Sponge Cacospongia mycofijiensis”. (J. Org. Chem. In press)

(19)           Taro Amagata, Makoto Tanaka, Takeshi Yamada, Katsuhiko Minoura, and Atsushi Numata. “Gymnastatins and Dankastatins, Growth Inhibitory Metabolites of Gymnacella Species from a Halichondria Sponge”. J. Nat. Prod. 2008, 71, 340-345.

(18)    Taro Amagata, Makoto Tanaka, Takeshi Yamada, Mitsunobu Doi, Katsuhiko Minoura, Hirofumi Ohishi, Takao Yamori and Atsushi Numata. “Variation in Cytostatic Constituents of a Sponge-Derived Gymnascellla dankaliensis by Manipulating the Carbon Source”. J. Nat. Prod. 2007, 70, 1731-1740.

(17)       Claudia M. Boot, Taro Amagata, Karen Tenney, Jennifer E. Compton, Frederick A. Valeriote, and Phillip Crews. “Four Classes of Structurally Unusual Peptides from Two Marine-Derived Fungi” Tetrahedron 2007, 63, 9903-9914.

(16)       Tyler A. Johnson, Karen Tenney, Robert H. Cichewicz, Brandon I. Morinaka, Kimberly N. White, Taro Amagata, Balanehru Subramanian, Joseph Media, Susan L. Mooberry, Frederick A. Valeriote and Phillip Crews. “Sponge-Derived Fijianolide Polyketide Class: Further Evaluation of Their Structural and Cytotoxicity Properties”. J. Med. Chem. 2007, 50, 3795-3803.

(15)       Hou-Jin Li, Taro Amagata, Karen Tenney and Phillip Crews. “Additional Scalarane Sesterterpenes from the Sponge Phyllospongia papyracea”. J. Nat. Prod. 2007, 70, 802-807.

(14)   Taro Amagata, Brandon I. Morinaka, Akiko Amagata, Karen Tenney, Frederick A. Valeriote, Emil Lobkovsky, Jon Clardy and Phillip Crews. “A Chemical Study of Cyclic Depsipeptides Produced by a Sponge-Derived Fungus”. J. Nat. Prod. 2006, 69, 1560-1566.

(13)   Taro Amagata, Katsuhiko Minoura and Atsushi Numata. “Gymnastatins F–H, Cytostatic Metabolites from the Sponge-Derived Fungus Gymnascella dankaliensis”. J. Nat. Prod. 2006, 69, 1384-1388.

(12)   Boaz Vilozny, Taro Amagata, Susan L. Mooberry and Phillip Crews. “A New Dimension to the Biosynthetic Products Isolated from the Sponge Negombata magnifica”. J. Nat. Prod. 2004, 67, 1055-1057.

(11)   Jeffrey T. Gautschi, Taro Amagata, Akiko Amagata, Frederick A. Valeriote, Susan L. Mooberry and Phillip Crews. “Expanding the Strategies in Natural Product Studies of Marine-Derived Fungi: A Chemical Investigation of Penicillium Obtained from Deep Water Sediment”. J. Nat. Prod. 2004, 67, 362-367.

(10)   Taro Amagata, Akiko Amagata, Karen Tenney, Frederick A. Valeriote, Emil Lobkovsky, Jon Clardy and Phillip Crews. “Unusual C25 Steroids Produced by a Sponge-Derived Penicillium citrinum”. Org. Lett. 2003, 5, 4393-4396.

(9)     Taro Amagata, Christopher Rath, Jérôme F. Rigot, Nick Tarlov, Karen Tenney, Frederick A. Valeriote and Phillip Crews. “Structures and Cytotoxic Properties of Trichoverroids and Their Macrolide Analogs Produced by Saltwater Culture of Myrothecium verrucaria”. J. Med. Chem. 2003, 46, 4342-4350.

(8)     Taro Amagata, Stephanie Whitman, Tyler A. Johnson, Chad C. Stessman, Christopher Loo, Emil Lobkovsky, Jon Clardy, Phillip Crews, and Theodore R. Holman. “Exploring Sponge-Derived Terpenoids for Their Potency and Selectivity against 12-Human, 15-Human, and 12-Soybean Lipoxygenases”. J. Nat. Prod. 2003, 66, 230-235.

(7)     Yoshihide Usami, Takashi Ikura, Error! Contact not defined. and Atsushi Numata. “First total syntheses and Configurational Assignments of Cytotoxic Trichodenones A-C”. Tetrahedron Asymmetry 2000, 11, 3711-3725.

(6)     Taro Amagata, Mitsunobu Doi, Makiko Tohgo, Katsuhiko Minoura and Atsushi Numata. “Dankasterone, a New Class of Cytotoxic Steroid Produced by a Gymnascella species from a Marine Sponge’. Chem. Commun. 1999, 1321-1322.

(5)     Taro Amagata, Mitsunobu Doi, Takatoshi Ohta, Katsuhiko Minoura and Atsushi Numata. “Absolute Stereostructures of Novel Cytotoxic Metabolites, Gymnastatins A – E, from a Gymnascella Species Separated from a Halichondria Sponge”. J. Chem. Soc. Perkin Trans. 1 1998, 3585-3599.

(4)     Taro Amagata, Katsuhiko Minoura and Atsushi Numata. “Gymnasterones, Novel Cytotoxic Metabolites Produced by a Fungal Strain from a Sponge”. Tetrahedron Lett. 1998, 39, 3773-3774.

(3)     Taro Amagata, Katsuhiko Minoura and Atsushi Numata. “Cytotoxic Metabolites Produced by a Fungal Strain from a Sargassum Alga”. J. Antibiot. 1998, 51, 432-434.

(2)     Taro Amagata, Yoshihide Usami, Katsuhiko Minoura, Tadayoshi Ito and Atsushi Numata. “Cytotoxic Substances Produced by a Fungal Strain from a Sponge: Physico-Chemical Properties and Structures”. J. Antibiot. 1998, 51, 33-40.

(1)     Atsushi Numata, Taro Amagata, Katsuhiko Minoura and Tadayoshi Ito. “Gymnastatins, Novel Cytotoxic Metabolites Produced by a Fungal Strain from a Sponge”. Tetrahedron Lett. 1997, 38, 5675-5678.