 |
Name: |
Amagata, Taro |
| Education: |
B.S. (1993)
Osaka University of Pharmaceutical Sciences, Japan.
M.S. (1995) Osaka University of Pharmaceutical
Sciences, Japan.
Ph.D. (1998) Osaka University of Pharmaceutical
Sciences, Japan. |
| At SFSU since: |
2008 |
| Status: |
Associate Professor |
| Office Location: |
TH641 |
| Phone: |
(415) 338-7713 |
| Email: |
 |
| Website: |
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Marine
Natural Products Chemistry
Marine invertebrates such as sponges and tunicates
have given continuous global attention as sources
for pharmaceutical leads over the past three
decades. Interestingly, recent studies have
disclosed some of bioactive substances separated
from marine invertebrates are produced by
microorganisms. My research group focuses on
exploring anti-cancer and anti-malaria potential
leads from marine obligate microorganisms separated
from marine sediments, algae and sponges. In my
group, isolation of novel bioactive secondary
metabolites is performed using concise and
sophisticated methods employing a combination of a
yeast halo assay and cutting edge dereplication
techniques. My group also plans to perform medicinal
chemistry and to identify gene clusters for
promising bioactive compounds through collaborative
research. |
|
Publications
[original articles, a
total of 33]
- Taro Amagata, Keiko Takigawa, Katsuhiko
Minoura, Atsushi Numata "Gymnastatins I-K,
Cancer Cell Growth Inhibitors from a
Sponge-Derived Gymnascella dankaliensis"
Heterocycles 2010, 81,
897-907.
- Mayumi Kitano, Takeshi Yamada, Taro
Amagata, Katsuhiko Minoura, Reiko Tanaka,
Atsushi Numata "Novel pyridino-alpha-pyrone
sesquiterpene type pileotin produced by a sea
urchin-derived Aspergillus sp." Tetrahedron
Lett. 2012, 53, 4192-4194.
- Taro Amagata, Jing Xiao, Yi-Pei Chen,
Nicholas Holsopple, Allen G. Oliver, Trevor
Gokey, Anton B. Guliaev, Katsuhiko Minoura
"Creation of an HDAC-Based Yeast Screen to
Evaluate Marine-Derived Actinomycetes: Discovery
of Streptosetin A" J. Nat. Prod. 2012,
75, 2193-2199.
- Kyoko Nakanishi, Mitsunobu Doi, Yoshihide
Usami, Taro Amagata, Katsuhiko Minoura,
Reiko Tanaka, Atsushi Numata, Takeshi Yamada "Anthcolorins
A-F, Novel Cytotoxic Metabolites from a Sea
Urchin-Derived Aspergillus versicolor" Tetrahedron
2013, 69, 4617-4623.
- Taro Amagata, Makoto Tanaka, Takeshi
Yamada, Yi-Pei Chen, Katsuhiko Minoura, Atsushi
Numata "Additional Cytotoxic Substances Produced
by a Sponge-Derived Gymnascella dankaliensis"
Tetrahedron Lett. 2013, 54,
5960-5962.
- Yi-Pei Chen, Chad C. Catbagan, Jeannette T.
Bowler, Trevor Gokey, Natalie D. M. Goodwin,
Anton B. Guliaev, Weiming Wu, Taro Amagata
"Evaluation of Benzoic Acid Derivatives as
Sirtuin Inhibitors" Bioorg. Med. Chem. Lett.
2014, 24, 349-352.
[review article]
- Taro Amagata "Case Examples from Past
Decades". In Comprehensive Natural Product
Chemistry II Chemistry and Biology;
Mander, L., Lui, H.-W., Eds.; Elsevier: Oxford,
2010; [Vol. 2], pp 581-621
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