Chemistry
and Biochemistry
College of Science and Engineering
Department of Chemistry and Biochemistry
TH 806
415-338-1288
Programs
B.A. in Chemistry
B.S. in Biochemistry
B.S. in Chemistry
Minor in Chemistry
M.S. in Chemistry
M.S. in Chemistry: Concentration in Biochemistry
Program Scope and Career Outlook
The Department of Chemistry and Biochemistry offers an outstanding educational environment for undergraduate and graduate students. The department's degree programs are designed to prepare students for graduate study, health professions programs, and professional careers such as teaching and laboratory positions with biotechnology and pharmaceutical companies. An important objective is to educate versatile chemists and biochemists who understand the theoretical basis and practical applications of their discipline and are well prepared to succeed in graduate school and professional positions.
The Bachelor of Arts in Chemistry is particularly well-suited for those students whose career goals involve the integration of chemistry with other fields. This program provides excellent preparation for pre-medical students and high school science teachers, as well as those who will pursue further studies in the pharmaceutical sciences, veterinary medicine, and dentistry. Additionally, the B.A. in Chemistry may be combined with a minor in engineering, business, social sciences, the humanities, or the arts to provide the student with a unique synthesis of experience applicable to careers in patent law, management, sales, marketing, chemical engineering, regulatory affairs, technical writing, scientific journalism, library science, environmental protection, and art restoration. Students who are considering teaching chemistry should consult with a credential adviser in the Department of Chemistry and Biochemistry before planning the major. Specific courses in competency assessment are required for the credential program.
The Bachelor of Science in Chemistry, which is approved by the American Chemical Society, prepares students to pursue a career in chemically-oriented industry or to begin graduate study in chemistry and other molecular sciences. The degree provides a solid foundation in mathematics and physics, breadth in traditional chemical subdisciplines (analytical, inorganic, organic, and physical chemistry), and depth in one or more areas of chemistry. This program provides excellent training in instrumental analysis and emphasizes quantitative and analytical aspects of the discipline.
The Bachelor of Science in Biochemistry is designed for those students who wish to be particularly well qualified in the rapidly expanding fields between biology and chemistry. The extensive laboratory training program provides exceptional preparation for careers in biotechnology and enjoys a favorable reputation among biotechnology companies in the Bay Area. This degree provides a strong foundation for a graduate degree in biochemistry, and it is an excellent degree choice for entry into medical or dental college.
The Master of Science in Chemistry, which is approved by the American Chemical Society, is designed as a balanced program in analytical, inorganic, organic, and physical chemistry, and biochemistry. The department also offers the Master of Science in Chemistry with a Concentration in Biochemistry for students who want to specialize in the biochemical aspects of chemistry. The American Chemical Society placement examinations, while not greatly influencing the graduate status of the student, will determine where individual weaknesses exist so that corrective emphasis may be applied. The department also offers a cooperative M.S./Ph.D. program with the University of California, Davis for defined minority students and women from all ethnic groups (contact the department chair for further information). Work leading to the master's degree should provide for the best possible balance between theoretical course work and research. A student completing the program should be prepared to pursue a career in the field of chemical research and development at the technical level, teaching, or have the necessary foundation to continue studies toward the doctorate.
The Committee on Professional Training of the American Chemical Society enthusiastically commended the department for the excellence of its undergraduate program. High-quality teaching, one-on-one advising, and opportunities for students to participate in research under the direct supervision of active faculty members who are recognized authorities in their field are significant features of the department. Chemistry and Biochemistry faculty members are actively involved in research, and many undergraduate students work on research projects during their senior year, working closely with their faculty research adviser. Examples of research projects currently under investigation by our faculty members and their research students include:
Analytical Chemistry: Evaluation of Martian soil analog materials. Development of new methods for direct monitoring of pollutants via mass spectrometry. Novel analytical techniques for separation and detection of redox-sensitive trace species.
Biochemistry: Enzyme reaction mechanisms. Synthesis of enzyme inhibitors, characterization of transition-state analogs, and measurement of enzyme-ligand interactions. Isolation and characterization of methyl transferase enzymes. Structure-function relationships in membrane transport proteins and mechanisms of membrane biogenesis, with emphasis on outer membrane proteins of Escherichia coli. Biosynthesis and regulation of the expression of complex carbohydrate cell surface antigens. Characterization of enzymes involved in the nitric oxide cellular signaling pathway.
Metalloprotein Biochemistry: Structural and functional studies of metalloproteins involved in redox reactions, oxygen activation, oxygen transport, and signal transduction.
Environmental Chemistry: Determination of structures and speciation of metals and trace elements adsorbed on environmental surfaces. Modeling speciation, precipitation, and adsorption reactions of trace elements in environmental systems. Mechanisms of heavy metal tolerance/accumulation in plants. Effects of heavy metals on gene expression in plants. Detection of trace levels of volatile organic compounds and heavy metals in urban air, water, and soil samples.
Inorganic/Bioinorganic Chemistry: Transition metal organometallic chemistry. Photochemistry and photophysics of organometallic compounds. Performance of thin-film polymer electrolytes. Development and applications of multi-dimensional NMR methodologies for the structural analysis of platinum complexes and paramagnetic molecules. Bioinorganic chemistry of paramagnetic Fe(III) porphyrins, chromium(III) complexes, and cobalt(II,III) complexes to model structure-function relationships of heme proteins, the glucose tolerance factor, and vitamin B12.
Organic/Bioorganic Chemistry: Reaction mechanisms and synthetic applications of organic peroxides. Small rings. Heterocyclic chemistry. Chemistry of singlet oxygen. Mechanisms of fundamental organic reactions: computational approaches to modeling the transition states of nucleophilic substitutions and elimination reactions. Conformations of small peptides. Structure-reactivity relationships in acid- and base-catalyzed organic reactions, including heterolytic cleavage of C-H and C-C bonds. Design and synthesis of substrate analogs to elucidate the catalytic mechanisms of enzymes. Design and synthesis of novel enzyme inhibitors for use in sensitizing tumor cells to common chemotherapeutic strategies.
Physical/Biophysical Chemistry: Characterization of structural features and dynamic behavior of natural and synthetic macromolecules in solution using physical methods and theoretical models. High precision computational modeling and electro-optic characterization of hydrodynamic transport properties of small, medium, and large molecules. Electrical and mechanical properties of nucleic acids, proteins, molecular motors, and protein-nucleic acid complexes. Biophysical applications of electron spin resonance spin labels. Diffusion and solubility of molecular oxygen in biomembranes and in other tissue. Biophysical spectroscopic methods, including nanosecond time-resolved polarized absorption spectroscopy, to characterize biological function and examine the molecular basis of disease.
Students obtain extensive hands-on training in the use of state-of-the-art research instruments and obtain valuable training in modern laboratory techniques and computational methods. These include, for example, nuclear magnetic resonance spectrometers, a state-of-the-art mass spectrometry facility, and numerous modern instruments. Computers are used extensively in chemistry classes, and the department's modern facilities include the Computational Chemistry and Visualization (CCV) laboratory. The CCV laboratory houses state-of-the-art computer workstations with 3D graphics capabilities and enables instructors to teach molecular modeling applications and computational chemistry in inorganic chemistry, physical chemistry, organic chemistry, and biochemistry lecture and laboratory courses.